This is a personal site focused on computational modeling and simulation (CM&S) for healthcare applications, with an emphasis on model credibility (“when can a computational model be trusted?”) and emerging CM&S/AI methods.
- Publications – My journal articles
- Talks – List of invited talks and select slides and recordings
- Resources – Selected links to resources that may be of interest to those in the broad healthcare modeling community
About Me
I am a Senior Research Scientist at the U.S. Food and Drug Administration (FDA), Center for Devices and Radiological Health (CDRH), where my work focuses on the role of computational modeling and simulation in medical device evaluation.
I led the development of the CDRH Guidance on model credibility, and have worked extensively on verification, validation, and uncertainty quantification (VVUQ) in this context. My work also explores how CM&S and machine learning methods can be combined in regulatory-relevant settings.
I have authored over fifty peer-reviewed publications (6000 citations, h-index 37) spanning cardiac electrophysiology, soft tissue mechanics, physiological closed loop control, patient-specific modeling, digital twins, and in silico clinical trials.
I co-founded FDA’s Modeling and Simulation Working Group and am a member of the ASME V&V40 Subcommittee on model credibility. I have a BA in mathematics from Cambridge University and a PhD in computational cardiology from Oxford University.
Selected Highlights
- 2025 Co-chair, MDIC Computational Modeling and Simulation Symposium: Credible Models in the Age of AI
- 2023 Led development of FDA CDRH Guidance on model credibility assessment
- 2022 Led development of FDA report “Successes and Opportunities in Modeling & Simulation for FDA”
- 2018–2022 Co-founded and co-chaired FDA Modeling and Simulation Working Group
- 2017-present Member, ASME V&V40 Subcommittee (model credibility standards)
- 2012-present Research Scientist, FDA/CDRH
- 2006-2013 Core developer of the Chaste computational physiology platform, leading cardiac and differential equation solver functionality
- 2007 DPhil (PhD), University of Oxford