This is a personal site sharing my publications, talks and other resources in computational modeling and simulation (CM&S) for healthcare applications, focusing on credibility (“when can a computational model be trusted?”) and emerging CM&S/AI methods.

About Me

I am a Senior Research Scientist at the U.S. Food and Drug Administration (FDA), Center for Devices and Radiological Health (CDRH), in OSEL, the Center’s regulatory science office. My work is focused on computational modeling and simulation for medical devices, covering both computational models used to evaluate devices and computational models embedded in device software.

I led the development of the CDRH Guidance on model credibility, and have published over fifty peer-reviewed publications (~6000 citations, h-index 37) spanning verification, validation and uncertainty quantification, patient-specific modeling and digital twins, in silico clinical trials, cardiac electrophysiology, soft tissue mechanics and physiological closed loop control.

I co-founded FDA’s Modeling and Simulation Working Group and am a member of the ASME V&V40 Subcommittee on model credibility. I have a BA in mathematics from Cambridge University and a PhD in computational cardiology from Oxford University.

Selected Highlights